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Symbol Name ID |
Cxcr4
C-X-C motif chemokine receptor 4 MGI:109563 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Gastrointestinal hemorrhage |
Retinal hemorrhage |
Purpura |
Vasculitis |
Stroke |
Congestive heart failure |
Lymphadenopathy |
Splenomegaly |
Abnormal retinal vascular morphology |
Cutis marmorata |
Urticaria |
| Disease(s) Associated with CXCR4 | |||||||||||
| lymphoplasmacytic lymphoma |
| Mouse Phenotypes | cardiovascular system phenotype |
abnormal blood vessel morphology |
poor arterial differentiation |
aortic arch hypoplasia |
right aortic arch |
double aortic arch |
aorta stenosis |
kidney vascular congestion |
abnormal skin vasculature morphology |
abnormal angiogenesis |
abnormal developmental vascular remodeling |
abnormal vasculogenesis |
abnormal vascular smooth muscle morphology |
perivascular fibrosis |
abnormal myocardial fiber morphology |
abnormal heart morphology |
thick mitral valve cusps |
abnormal interventricular septum morphology |
perimembraneous ventricular septal defect |
muscular ventricular septal defect |
ventricular septal defect |
increased heart weight |
cardiac hypertrophy |
aortic valve atresia |
abnormal heart right ventricle outflow tract morphology |
cardiac interstitial fibrosis |
small intestine hemorrhage |
kidney hemorrhage |
decreased ventricle muscle contractility |
decreased left ventricle systolic pressure |
cardiomyopathy |
congestive heart failure |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||
| Cxcr4b2b220Clo/Cxcr4b2b220Clo | |||||||||||||||||||||||||||||||||
| Cxcr4em1(IMPC)Mbp/Cxcr4em1(IMPC)Mbp | |||||||||||||||||||||||||||||||||
| Cxcr4tm1Qma/Cxcr4tm1Qma | |||||||||||||||||||||||||||||||||
| Cxcr4tm1Tng/Cxcr4tm1Tng | * | ||||||||||||||||||||||||||||||||
| Cxcr4tm1Yzo/Cxcr4tm1Yzo | |||||||||||||||||||||||||||||||||
| Cxcr4tm3.1Yzo/Cxcr4tm3.1Yzo | |||||||||||||||||||||||||||||||||
| Cxcr4tm2Yzo/Cxcr4tm2Yzo Tg(Myh6-cre)2182Mds/0 (conditional) |
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| Cxcr4tm1Tng/Cxcr4tm2Tng Tg(Tek-cre)12Flv/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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